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    Archived pages: 893 . Archive date: 2012-07.

  • Title: Welcome to the ALS Society of Canada
    Descriptive info: .. English.. Visit ALS Society of Canada.. Continue.. Français.. Visitez la Société canadienne de la SLA.. Continuer.. ALS Society of Canada.. Société canadienne de la SLA.. ALS Society of Canada 3000 Steeles Avenue East, Suite 200 Markham, Ontario L3R 4T9.. Toll Free: 1-800-267-4257 T: 905-248-2052 F: 905-248-2019.. ALS support group forums by.. ALSforums.. Drupal website design and web development by.. Intrigue Design..

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  • Title: Home | ALS Society of Canada
    Descriptive info: Funding Research.. Increasing Awareness.. Supporting Care.. Research.. ALS Research.. Research Updates.. Fund a Research Grant.. Clinical Trials.. CALS.. Phase III – Dexpramipexole clinical trial.. Phase III – Ceftriaxone clinical trial.. Canadian Neuromuscular Disease Registry (CNDR).. Meet ALS Researchers.. Research Programs.. Basic Science Grants.. Bernice Ramsay Innovation Grants.. Canadian Neuromuscular Disease Registry - ALS Component.. Clinical Trials and Clinical Research.. Annual Research Forum.. Neuromuscular Research Partnership (NRP).. Stem Cells.. Glossary.. Living with ALS.. Register with Your Provincial Society.. ALS Clinics.. Benefits for Veterans.. Veterans Tribute Wall.. Support Education.. Life with ALS.. Stories.. Videos.. Get Involved.. Advocacy.. Host Your Own Event.. School Fundraisers.. Community Fundraisers.. Workplace Fundraisers.. WALK for ALS ®.. ALS Yoga Challenge.. Betty s Run ®.. Hike for ALS ®.. ALS Charity Golf Classic.. Scotiabank Toronto Waterfront Marathon.. Volunteering.. ALS Awareness.. ALS March of Faces.. Publications and Resources.. Care Resources.. A Manual for People Living with ALS.. Coping with Grief.. Physician CD.. ALS Care Guidelines.. The How To Health Guide.. Web Resources.. Summary List of Educational Resources.. Youth Resources.. Youth Retreat.. Youth Website.. Publications.. 2012 Research Report.. Research Newsletter.. Northern Neuron.. Coast to Coast Newsletter.. Books/DVDs.. Articles and Information About ALS.. ALS Canada Milestones.. Responding to the reader - What is amyotrophic lateral sclerosis?.. Test Your ALS IQ.. Annual Report.. ALS Fact Sheets.. Media PSAs.. Media.. Public Service Announcements.. Helping Someone with ALS.. Press Releases.. News Archive.. About Us.. Mission Vision.. Meet the President.. Board of Directors.. Message from our CEO.. Staff Directory.. Contact Us.. DONATE.. General Donations.. Memorial/Tribute.. One Time Donation.. Create/Find a Fund.. Light a Candle.. Plant a Flower.. Monthly Giving.. Planned Giving.. Donor Advised Funds.. Special Occasions.. Donate to an Event.. ALS (also known as Lou Gehrig s Disease) is a progressive neuromuscular disease in which nerve cells die and leave voluntary muscles paralyzed.. Every day two or three  ...   Ontario have announced that the two organizations are to be combined to sustain and enhance client services in Ontario and in Canada and to fund and administer the national research program.. David Taylor, PhD, Director of Research – ALS Society of Canada.. The ALS Society of Canada is pleased to announce that David Taylor, PhD, joined the ALS Canada team on May 28, 2012.. Immunization Therapy Progress.. A team of Canadian ALS researchers at the University of Toronto published a study entitled Targeting of Monomer/Misfolded SOD1 as a Therapeutic Strategy for ALS, in the June 27, 2012 issue of.. The Journal of Neuroscience.. This work identifies how specific, targetable species of SOD1 are responsible for disease and demonstrates that their effective neutralization can significantly alter disease in an ALS mouse model.. Archetypes by Blair Polischuk.. Archetypes is available free of charge for download on your iPhone, iPad, or iPod touch with iBooks and on your computer with iTunes.. Books must be read on an iOS device.. Click here to download.. A retrospective collection of classical black-and-white photographs by Blair Polischuk - a Canadian artist living with ALS.. All News.. Our Mission.. The mission of the ALS Society of Canada is to fund research towards a cure for ALS and support provincial ALS Societies to provide quality care for those affected by ALS.. More About Us.. Our Twitter Feed.. ALSCanada.. ALS Yoga Challenge | ALS Society of Canada:.. t.. co/LEgzKll5.. 12 hours 27 min ago.. Like us on FaceBook.. Follow us.. ALS Newsletter.. Keep up-to-date on the latest news at the ALS Society of Canada by subscribing to our eNews.. Society Login.. If you are an ALS associate and have a username and password, please login below.. Username:.. *.. Password:.. Request new password.. ALS Society of Canada Registered Charity 10670-8977-RR0002.. Contact.. Privacy Policy..

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  • Title: Page d'accueil | SOCIÉTÉ CANADIENNE DE LA SLA
    Descriptive info: Financement de la recherche.. Soutenir les soins.. Sensibilisation.. Recherche.. Recherche sur la SLA.. Développements de la recherche.. Financement d’une subvention de recherche.. Essais cliniques.. Essai clinique de phase III sur le dexpramipexole.. Essai clinique de phase III sur le ceftriaxone.. CNDR (Canadian Neuromuscular Disease Registry).. Chercheurs de la SLA.. Programmes de recherche.. Subventions de recherche : science fondamentale.. Subventions de recherche : innovation.. Composante SLA du CNDR.. Essais et travaux de recherche clinique.. Forum annuel sur la recherche.. Partenariat de recherche sur les maladies neuromusculaires (PRMN).. Cellules souches.. Lexique.. Vivre avec la SLA.. Inscrivez-vous auprès de votre société provinciale.. Cliniques de la SLA.. Prestations pour les anciens combattants.. Hommage aux anciens combattants.. Soutien et éducation.. La vie avec la SLA.. Témoignages.. Vidéos.. Engagez-vous.. Défense de la cause.. Organisez votre propre événement.. Collecte de fonds dans une école.. Collecte de fonds dans la collectivité.. Collecte de fonds en milieu de travail.. MARCHE pour la SLA.. Course de Betty.. Randonnée pour la SLA.. Classique de golf ALS Charity.. Bénévolat.. Sensibilisation à la cause.. Parade des visages de la SLA.. Publications et ressources.. Ressources en matière de soins.. Manuel pour les personnes qui vivent avec la SLA.. Faire face au deuil.. CD-ROM à l’intention des médecins.. Lignes directrices pour les soins.. Le Guide Santé Pratique.. Ressources sur le Web.. Ressources pour les jeunes.. Week-end d’activités pour les jeunes.. Site Web destiné aux jeunes.. Bulletin sur la recherche.. Bulletin Neurone du Nord.. Bulletin D’un océan à l’autre.. Livres et DVD.. Articles et autres renseignements sur la SLA.. Étapes marquantes de la Société canadienne.. Chronique Réponses aux lecteurs Qu’est-ce que la sclérose latérale amyotrophique?.. Essayez de répondre à notre jeu questionnaire sur la SLA!.. Rapport annuel.. Fiches de renseignements sur la SLA.. Médias et messages d’intérêt public.. Médias.. Messages d’intérêt public.. Aidez une personne atteinte de la SLA.. Communiqués de presse.. Archive des nouvelles.. À propos de nous.. Mission et vision.. Présidente de la Société canadienne.. Conseil d’administration de la Société canadienne.. Message de la chef de la direction.. Répertoire du personnel.. Contactez-nous.. Donnez.. Dons généraux.. Dons en commémoration et en hommage.. Don unique.. Créer ou trouver un fonds.. Allumer une bougie.. Planter une fleur.. Dons mensuels.. Dons planifiés.. Fonds de bienfaisance.. Occasions spéciales.. Dons à un événement..  ...   occasion de sa cérémonie annuelle de remise de prix qui aura lieu au Sheraton Gateway Hotel de Toronto le samedi 28 avril.. En voici les lauréats :.. Les déficiences du transport axonal et la dégénérescence se développent de manière indépendante.. Des chercheurs de Munich, en Allemagne, ont publié une étude intitulée Les déficiences du transport axonal et la dégénérescence peuvent évoluer de manière indépendante dans les.. Modèles cellulaires axés sur les astrocytes pour l’étude du rôle potentiel de ces cellules dans la SLAs.. La SLA se caractérise par la dégénérescence des motoneurones dans la moelle épinière et le tronc cérébral.. Les chercheurs se servent donc de modèles souris pour étudier ce phénomène.. À ce chapitre, les avancées les plus notables ont été réalisées à l aide de modèles reproduisant.. Annonce des titulaires des bourses Bernice Ramsay.. La Société canadienne de la SLA est heureuse d annoncer le nom des titulaires des bourses Bernice Ramsay 2011, décernées relativement à trois projets de recherche canadiens.. La Société canadienne de la SLA s inscrit pour une deuxième année au marathon Scotiabank Toronto Waterfront.. Markham, ON, 8 mars 2012 la Société canadienne de la SLA s est de nouveau inscrite au défi caritatif du marathon Scotiabank Toronto Waterfront, lequel aura lieu le 14 octobre 2012, et demande à tous de courir ou marcher pour ceux qui ne peuvent pas parce qu ils souffrent de la SLA.. Toutes les nouvelles.. Notre mission.. La mission de la Société canadienne de la SLA consiste à financer la recherche en vue d un traitement définitif et de soutenir les sociétés provinciales dans la prestation de soins de qualité pour les personnes atteintes.. En savoir plus sur nous.. Notre fil Twitter.. Aimez-nous sur Facebook.. Suivez-nous.. Bulletin électronique.. Tenez-vous au courant des dernières nouvelles de la Société canadienne de la SLA en vous abonnant à notre Bulletin électronique.. Ouverture de session pour le personnel.. Si vous êtes membre du personnel de la Société et que vous possédez un nom d utilisateur et un mot de passe, veuillez utiliser les champs ci-dessous pour vous identifier.. Nom d’utilisateur :.. Mot de passe :.. Demander un nouveau mot de passe.. SOCIÉTÉ CANADIENNE DE LA SLA ORGANISME DE BIENFAISANCE ENREGISTRÉ N 10670-8977-RR002.. CONTACT.. POLITIQUE SUR LA VIE PRIVÉE..

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  • Title: ALS Research | ALS Society of Canada
    Descriptive info: Research takes time.. A typical research project involves a hypothesis, or question to be answered, and lasts three - five years.. Often, as a project is underway, new questions arise.. Thus a single project often leads directly into a new project.. The goals of ALS research projects are to understand the mechanisms of motor neuron death and to identify ways to keep motor neurons alive and functioning normally.. Motor neurons are the cells in the brain and spinal cord which are responsible for conscious muscle contraction (i.. e.. , function).. These nerve cells are the primary target for degeneration in ALS.. In order to understand what motor neurons need to function correctly they need to be studied under normal conditions, and then in situations where they are stressed.. Examples of stress can be changes in oxidative state, changes in expression of specific genes or proteins, or exposure to varying levels of compounds which are toxic.. Motor neurons can be studied just as an isolated cell population ( in the dish ), or in combination with other types of cells (also in the dish ).. To study the cells in more detail, genes (i.. , DNA) or proteins may be isolated from inside the cells and then examined using state-of-the-art technology.. In some cases, the functional properties of proteins with very specific locations in the motor neurons (i.. , receptors in the membrane, or intracellular organelles responsible for generating energy) are measured using other highly sophisticated techniques.. Research costs money.. One single research project costs on average $120-140,000 per year for three to five years.. This cost does not include the salary support for the principal investigator (basic scientist or clinician) or for graduate students or research fellows responsible for carrying out the project.. Basic science discoveries lead to candidate ALS therapies.. Whenever there is a promising lead from this type of basic science work, it needs to then be verified in studies using animal models of ALS.. A number of such models exist; these primarily use mice.. There are also a few rat models which are more useful for testing therapeutic interventions that require surgical approaches.. Animal studies require one - two years to carry out.. Positive results from such preclinical trials then need to be embraced by the pharmaceutical industry to be developed into therapies which are safe and can be effectively targeted to the nervous system in humans.. Important developments in the past 10 years.. The past 15 years have seen an enormous growth in the number of research projects (both basic and clinical) devoted to ALS.. Here we will mention just a few of the important areas which have been the focus of research during the past 10 years:.. Glial role/ inflammation.. | Motor neurons in the brain and spinal cord are in contact with a large number of surrounding cells.. Some of these are also nerve cells, but many of them are not.. Those cells, called glia, serve to provide and maintain a supportive environment for motor neurons.. Recently, it was also recognized that the glial cells can undergo changes which make them aggressively harmful.. That process is known as neuroinflammation.. Approximately 10 years ago, anti-inflammatory drugs were tested as likely agents to slow or halt the progression of ALS.. The clinical trials were not successful.. Since those disappointing results, a number of labs have gone on to study the glia and the neuroinflammatory process in much greater detail, in order to identify better compounds and therapeutic delivery strategies.. One new agent believed to act on this system is entering clinical trials shortly.. ALS Canada funds research in the area of neuroinflammation.. Stem cells.. | Stem cells are undifferentiated cells which have the potential to divide and turn into a number of differentiated cell types.. Legal and ethical issues surrounded the isolation and characterization of human stem cells, limiting the study and testing of such cells for therapeutic approaches.. Several years ago, the possibility of using cells isolated from adult human skin (or some other tissue sources) to prepare stem cell-like populations has led to an explosion of research in this field.. Studies published since the original discovery have confirmed that skin isolated from ALS patients can be used to produce stem cells which have many of the characteristics of embryonic or fetal stem cells.. Further work is now underway to define and confirm the factors needed to turn such stem cells into motor neurons or into cells which might surround the motor neurons  ...   motor neurons which eliminate problem proteins are currently being developed and one is being tested in early stage clinical trials.. Also within the past five years, studies demonstrated that the mutant or misfolded SOD1 protein can be secreted from motor neurons ( in the dish ) and that the protein can then be taken up by adjacent cells.. One leading current hypothesis is that this phenomenon may be the basis of the inflammatory process carried out by the glial cells which surround motor neurons, and further, may play a major role in the progression of motor neuron degeneration from one region of the nervous system to another.. ALS Canada funds research in the processing of misfolded proteins and in strategies to neutralize mutant proteins after they are secreted from motor neurons.. Mitochondria.. | Mitochondria are tiny vesicles found inside all cells of the body.. They are the energy generators of the cells.. Motor neurons require a lot of energy to communicate signals which originate in the brain to their ultimate target the muscle.. Thus, motor neurons typically contain high numbers of mitochondria.. Mitochondria also serve to monitor important molecules which indicate the overall state of the cell s health; when certain signal molecules are present, cell death pathways are activated.. These vesicles have been a constant subject of study with respect to ALS for the past 15 years.. The studies continue to confirm the critical role of mitochondria in motor neuron survival and provide more and more sophisticated details about their roles in intracellular regulation.. A new clinical trial of a compound believed to be neuroprotective by supporting mitochondria entered Phase III (the final stage of a clinical trial) at the beginning of this year.. This very large scale study is taking place at centres in the U.. , Canada, and Europe.. ALS Canada funds research to characterize the roles of the mitochondria in healthy motor neuron function.. Biomarkers.. | A serious challenge in the treatment of ALS patients is the length of time between first clinical visit related to symptoms, and formal diagnosis of ALS.. Diagnosis can take up to 18 months; this period is considered to be an important window of opportunity to slow the progression and protect the motor units which remain functional.. Biomarkers to confirm diagnosis or document progression are a goal of several research projects funded by ALS Canada.. Examples are studies of mRNA and protein isoforms serving as barcodes (Janice Robertson and lab members) work funded by the NRP and doctoral and postdoctoral fellowships; and use of muscle unit number estimation (MUNE) as a surrogate marker of progression (Sanjay Kalra and Ming Chan) work funded jointly with ALSA.. ALS Canada.. We have learned in the past 10 years about ALS confirms that it is a complex disorder involving not only the known target cells (motor neurons) but additional types of cells which can either protect and support the neurons, or lead to disease progression.. Thus it is believed that effective treatment will likely involve more than one therapeutic agent, targeting several of the known mechanisms instead of just one.. It is important to understand that research breakthroughs can occur at any time, in any of the areas described above, or in additional research fields.. Thus it is critical to fund as many projects in parallel as possible, to identify mechanisms and related therapeutic approaches for clinical trial.. To follow through on this, ALS Canada:.. Supports three year full operational grants for established ALS scientists, for (on average) three new lab projects every year.. Works in partnership with other agencies (both federal and private) to maximize the number of ALS projects which can be funded.. Supports the development of young investigators by providing three-year doctoral and postdoctoral fellowships to (on average) three new candidates every year.. Provides seed money for highly innovative projects which bring new methodologies and new researchers into the ALS field.. Provides funding for specialized training of neurologists in clinical research and care of ALS patients.. Enables Canadian scientists and clinicians to share results and discuss research priorities by funding an annual pan-Canadian Research Forum, and by providing travel stipends to the annual International ALS/MND symposium.. Supported the foundation in 2008 of the Canadian clinical trials and research network (CALS) which has 15 Centres across Canada and is currently running its second and third national clinical trials.. Supports the establishment of a national ALS Registry as a module of the Canadian Neuromuscular Disease Registry (CNDR) based at the University of Calgary..

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  • Title: ALS Awareness | ALS Society of Canada
    Descriptive info: Raising awareness of ALS is a key program of the ALS Society of Canada and its Provincial.. Societies.. All of our activities have an element of awareness to them and we are always looking for more opportunities to bring ALS to the attention of the Canadian public.. June is ALS Awareness Month.. June is ALS month.. Locally individuals and groups take on a wide range of activities to raise awareness in their community.. The ALS Society of Canada supports these efforts with information and other support materials.. We also distribute public service announcements to media across the country.. If you are interested in developing a public awareness project or would like to know more, please contact Bobbi Greenberg, Director of Communications, 1-800-267-4257 ext.. 208 or.. bg@als.. ca.. Would you like to know more?.. The ALS Society draws on the knowledge of numerous experts to speak on various aspects of ALS and the role of the ALS Society.. To arrange a speaker for any particular subject, please contact Bobbi Greenberg, Director of Communications, 1-800-267-4257 ext.. The ALS Cornflower: A Symbol of Hope.. The Cornflower (Centaurea cyanis) is a native annual/ biennial plant from Mediterranean Europe.. Representing positive hope for the future, the Cornflower is a humble reminder of nature s simple beauty and the fullness of life s cycle.. The Blue Cornflower is to ALS what the Daffodil is to Cancer.. they are the Flower of Hope for both diseases.. The Blue Cornflower is the international flower of hope for ALS/ MND.. The Blue Cornflower plant is a very courageous plant, being able to stand up all the elements of nature (something many other plants cannot do) and the flower, with its  ...   fairly common in cultivated fields and by roadsides.. The stems are 1 to 3 feet high, tough and wiry, slender, furrowed and branched, somewhat angular and covered with a loose cottony down.. The leaves, very narrow and long, are arranged alternately on the somewhat dull and gray appearance.. The lower leaves are much broader and often have a roughly-toothed outline.. The flowers grow solitary, and of necessity upon long stalks to raise them among the corn.. The bracts enclosing the hard head of the flower are numerous, with tightly overlapping scales, each bordered by a fringe of brown teeth.. The inner disk florets are small and numerous, of a pale purplish rose colour.. The bright blue ray florets, that form the conspicuous part of the flower, are large, widely spread, and much cut into.. The flowers are used in modern herbal medicine, as they are considered to have tonic, stimulating properties, with action similar to that of Blessed Thistle.. A water distilled from Cornflower petals was formerly in repute as a remedy for weak eyes.. The famous French eyewash, Eau de Casselunettes , used to be made from them.. The powder of the dried leaves has been used to treat those that are bruised by a fall of have broken a vein inwardly.. The seeds or leaves taken in wine is are good for treating infectious diseases, and are very good in pestilential fevers.. The expressed juice of the petals makes a good blue ink; if expressed and mixed with alum-water, it may be used for water-colour painting.. It dyes linen a beautiful blue, but the colour is not permanent.. The dried petals are used by perfumeries for giving colour to pot-pourri..

    Original link path: /get-involved/als-awareness
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  • Title: Register with Your Provincial Society | ALS Society of Canada
    Descriptive info: The ALS Society of Canada works with the provincial ALS Societies, which develop local chapters and support groups and provide direct support to people with ALS, their families and caregivers.. The provincial societies also offer information and referrals, and support for those affected by ALS.. They manage equipment programs and engage  ...   health-care providers.. If you would like to contact a provincial society, please click on your province below to find the phone numbers, contact persons, websites, and email addresses of the ALS organizations nearest you.. Alberta.. British Columbia Yukon.. Manitoba.. New Brunswick.. Newfoundland and Labrador.. Nova Scotia.. Ontario.. Prince Edward Island.. Quebec.. Saskatchewan..

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  • Title: ALS Research | ALS Society of Canada
    Original link path: /en/research/our-research-program
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  • Title: Research Updates | ALS Society of Canada
    Descriptive info: CURRENT RESEARCH NEWS.. Axonal transport deficits and degeneration develop independently.. Researchers from Munich, Germany published a study entitled, Axonal transport deficits and degeneration can evolve independently in mouse models of ALS, that challenged a widely.. RESEARCH NEWS ARCHIVE.. January 2011.. (2).. February 2011.. (5).. March 2011.. (1).. June 2011.. July 2011.. August 2011.. (6).. September 2011.. October 2011.. November 2011.. December 2011.. January 2012.. March 2012.. (4).. July 2012..

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  • Title: Fund a Research Grant | ALS Society of Canada
    Descriptive info: The Role of the ALS Society of Canada: The ALS Society of Canada is committed to funding research towards a cure for ALS and supporting provincial societies in their provision of quality care for people living with ALS and their families.. ALS Canada identifies and initiates excellent, peer-reviewed ALS research, conducted by some of the most renowned scientists in the world, working in Canada.. Recent developments have been encouraging.. Canadians can become involved in our important cause by holding events to raise funds for ALS research and programs.. Using proceeds from these initiatives, our research funding commitments will total $1.. 7 million in 2011.. The Neuromuscular Research Partnership (NRP), created in 1999, is a collaboration between ALS Canada and Muscular Dystrophy Canada, in partnership with the Canadian Institutes of Health Research, (Institute of Genetics, Institute of Musculoskeletal Health and Arthritis, and Institute of Neurosciences, Mental Health and Addiction).. For decades, Canadian researchers have been world leaders in the search for the causes, cures and treatment of muscular dystrophy and other neuromuscular disorders.. NRP funding promotes the development and sharing of expertise in neuromuscular research, and does much to ensure that well-established investigators, as well as promising young investigators, continue to carry out research which will lead to the development of treatments for ALS.. We fund only the most promising projects by the finest scientists and, over the years, this strategy has been rewarded with significant advances in our knowledge of  ...   at the Annual General Meeting.. Recognition on web site and through Facebook Twitter.. Description:.. Fellowship in ALS Research: A fellowship recognizes and supports post-doctoral ALS researchers by awarding each recipient up to $55,000 annually for a maximum of three years.. The aim of the fellowship is to encourage young scientists to pursue ALS research.. Each fellowship is a commitment of $55,000 annually for three years, totaling $165,000.. , John Doe/Jane Smith Fellowship in ALS Research.. Clinical Fellowship in ALS Research: A new initiative beginning in 2009, this program supports specialized training in clinical care and research skills related to ALS.. The program awards a researcher $100,000 per year for two years, encouraging newly trained neurologists to specialize in ALS and conduct clinical research and clinical trials in Canada.. Cost of Grant:.. The award is $100,000 annually for two years, totaling $200,000.. , John Doe/Jane Smith Clinical Fellowship in ALS Research.. Discovery Grants: This ALS Canada grant program was initiated in 2008 to fund high-novelty, high-risk and potentially high-impact research proposals.. Each recipient receives a one-time grant to pursue new and promising avenues in ALS research.. The award for each grant is $100,000 to be used within 12 - 24 months.. , John Doe/Jane Smith Discovery Grant.. For more information on funding a promising research grant, please contact:.. David Taylor, PhD.. Director of Research.. ALS Society of Canada.. 1-800-267-4257 x 202.. dt@als.. Enzo Raponi.. Director of Development.. 1-800-267-4257 x 205.. er@als..

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  • Title: Clinical Trials | ALS Society of Canada
    Descriptive info: What is a clinical trial?.. A clinical trial is a research study using human volunteers to study the safety and effectiveness of a drug, treatment, or device in changing the course of health outcomes.. Clinical trials follow basic scientific research that has been conducted to better understand disease pathways and pre-clinical studies that test treatment effects in the laboratory.. Trials can be conducted to prevent (e.. g.. , immunization trials) or treat disease (e.. , drug and therapeutic device trials).. In ALS research, most trials have been drug trials.. Drug trials study whether experimental (new) treatments or new ways of using known therapies are safe and effective under controlled conditions outlined in the study protocol.. What is a study protocol?.. A protocol is an action plan based on strict scientific and ethical principles that describes how the study will be conducted and how the patients safety will be protected.. The protocol will outline the number of participants needed, eligibility criteria (patient characteristics required for inclusion) such as age, gender, medical history, etc.. , tests that will be performed, length of the trial, treatment details, and side effects that may occur.. Why are clinical trials important?.. Until a cure for a disease is found, it is necessary to continue to search for better, safer, and faster acting treatments to halt or slow down the progression of the disease.. Since riluzole (Rilutek ), the only currently approved drug for ALS, has a very modest effect on extending life, other treatments still need to be developed and tested to more effectively treat ALS.. Understanding Clinical Trial Phases.. Treatments under study must go through several phases of testing before conclusions about safety and effectiveness can be drawn.. It can take up to five years or longer to develop drugs before human testing begins.. In Canada, prior to initiating a clinical trial, the drug developer (usually a pharmaceutical company) must apply to the Therapeutic Products Directorate (TPD) of Health Canada for permission to test on humans.. Phase I - Researchers test a new drug or treatment in a small group of people to assess its safety, determine a safe dosage range, and identify side effects.. Phase II - The drug or treatment is given to a larger group of people to see if it is effective to further evaluate its safety.. Phase III - The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow  ...   Potential time involved with traveling to the study site, receiving treatment, tests, and possible hospital stays.. Potential costs associated with travel to study site.. How safe are clinical trials?.. Clinical trials in Canada are regulated by the previously mentioned TPD, similar in function to the FDA in the United States.. All federally regulated trials must be approved and monitored by an independent committee of doctors, scientists, advocates and others to ensure safety.. These committees are called Institutional Review Boards (IRBs) or Ethics Review Boards (ERBs).. The review boards study and approve all study-related documents such as protocols, Informed Consent forms, physician credentials and eligibility, and patient recruitment methods.. Data and Safety Monitoring Committees are also common to clinical trials.. These independent groups of experts carefully monitor data to detect benefit or harm, and validity of results.. What is Informed Consent?.. Being given all the facts about a clinical trial before deciding to take part is known as informed consent.. A printed consent form that outlines key details of the study including those related to tests, treatments, potential risks, benefits, or side effects, and participant rights and responsibilities is provided.. Before signing a member of the research team should also discuss the study with you and answer any questions.. When you decide to join a trial, you are required to first sign the consent form.. You have the right to continue to ask questions throughout the study period and withdraw your consent at any time.. Questions to ask your doctor if you are considering participating in a trial.. What is the purpose of the study? Does this support progress toward a better treatment and cure for ALS and how? Who has reviewed and approved the study?.. Who are the sponsors? Who will be paying for the treatments and tests? How does the money get spent?.. What are the risks and benefits and how does this compare with other treatments available?.. What kinds of tests and procedures will be required? Where will they take place?.. How long will I receive the treatment? Will it be available after the trial is over? Will there be follow-up after the study is over?.. Will the study require extra time, effort, or expenses on my part?.. What does my family need to know?.. Where can I learn more about the study and the researchers? Are there any previous publications by the researcher related to this study?.. To learn more about clinical trials in general, conduct a search on the internet using the key words: clinical trials..

    Original link path: /en/research/clinical-trials
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  • Title: CALS | ALS Society of Canada
    Descriptive info: Canadian ALS Research Network (CALS).. Created and operated by its physician members, the Canadian ALS Research Network (CALS) is a national alliance of leading ALS clinicians and researchers committed to the expansion of ALS clinical research studies in Canada and to the pursuit of effective therapies for patients with ALS.. This includes both investigator and industry initiated multicentre national and international studies testing promising therapeutics for patients with ALS.. CALS is a non-profit, non-share corporation which is supported by the ALS Society of Canada and is a recognized affiliate society of the Canadian Neurological Sciences Federation (CNSF).. CALS has a cooperative relationship with the Northeast ALS Consortium (NEALS)  ...   trials.. CALS collectively offers national access to key patient groups, clinical-research expertise and best practice methodology, in a mutual quest to bring better treatments to market efficiently and effectively for patients with ALS.. With numerous ALS research centres of excellence (15) across Canada, CALS facilitates collaborative research initiatives that cannot be achieved by a single centre.. CALS sites provide a multidisciplinary approach to the care of patients with ALS and their families.. With well established research infrastructure including ALS outcomes measure certification and experience in International ALS clinical trial, CALS can rapidly and efficiently accrue subjects for clinical studies.. For more information:.. Email:.. contact@alsnetwork.. Telephone: (416)480-6860.. Web:.. http://www.. alsnetwork..

    Original link path: /en/research/cals
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